IGF-I promotes peripheral nervous system myelination

Ann N Y Acad Sci. 1999 Sep 14:883:124-30.

Abstract

Insulin-like growth factor-I (IGF-I) promotes the proliferation and differentiation of Schwann cells (SC). We use SC/dorsal root ganglion neuron (DRG) cocultures to examine the effects of IGF-I on the interaction between axons and SC. As SC extend processes toward the axon in the presence of IGF-I, these processes attach to and ensheath axons. Continued IGF-I exposure leads to enhanced P0 expression and long-term myelination. No myelination occurs in the absence of IGF-I. These data imply that IGF-I is critical not only for SC attachment and ensheathment of axons but also for long-term myelination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Cell Division / drug effects
  • Cells, Cultured
  • Coculture Techniques
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / drug effects
  • Ganglia, Spinal / physiology*
  • Insulin-Like Growth Factor I / pharmacology*
  • Myelin P0 Protein / biosynthesis
  • Myelin P0 Protein / genetics
  • Myelin Sheath / drug effects
  • Myelin Sheath / physiology*
  • Myelin Sheath / ultrastructure
  • Neurons / cytology
  • Neurons / physiology*
  • Peripheral Nerves / cytology
  • Peripheral Nerves / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Schwann Cells / cytology
  • Schwann Cells / drug effects
  • Schwann Cells / physiology*

Substances

  • Myelin P0 Protein
  • Insulin-Like Growth Factor I