Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation

Biosci Biotechnol Biochem. 1999 Oct;63(10):1811-2. doi: 10.1271/bbb.63.1811.

Abstract

Zerumbone was isolated from the rhizomes of Zingiber zerumbet Smith as a potent inhibitor of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. The IC50 value of zerumbone (0.14 microM) is noticeably lower than those of the anti-tumor promoters we have hitherto obtained. Interestingly, alpha-humulene lacking the carbonyl group at the 8-position in zerumbone was inactive (IC50 > 100 microM), while 8-hydroxy-alpha-humulune was markedly active (IC50 = 0.95 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / isolation & purification
  • Anticarcinogenic Agents / pharmacology*
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Herpesvirus 4, Human / growth & development*
  • Humans
  • Inhibitory Concentration 50
  • Kinetics
  • Monocyclic Sesquiterpenes
  • Plant Extracts
  • Plants, Medicinal
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Tetradecanoylphorbol Acetate / antagonists & inhibitors*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Tumor Cells, Cultured
  • Virus Activation / drug effects*
  • Zingiberales / chemistry*

Substances

  • Anticarcinogenic Agents
  • Monocyclic Sesquiterpenes
  • Plant Extracts
  • Sesquiterpenes
  • zerumbone
  • humulene
  • Tetradecanoylphorbol Acetate