Odontogenic ghost cell tumor is a rare epithelial odontogenic tumor that is the neoplastic counterpart of the calcifying odontogenic cyst. There is confusion and controversy in the literature regarding the integration or segregation of these 2 lesions. It shows many histologic features with ameloblastoma but in addition has characteristic ghost cells and dentinoid. It occurs within the maxillary and mandibular bones (central) and in the gingival soft tissues (peripheral). Peripheral tumors are treated with simple excision. Although central tumors are often amenable to curettage or simple excision, some tumors have been more aggressive and require partial resection of the jaw. Malignant tumors with similar features have been reported. This is a US government work. There are no restrictions on its use.