In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole

J Antimicrob Chemother. 1999 Oct;44(4):553-5. doi: 10.1093/jac/44.4.553.


The MICs of amphotericin B and itraconazole for 230 isolates of Aspergillus spp., comprising 156 Aspergillus fumigatus, 20 Aspergillus terreus, 22 Aspergillus flavus, 17 Aspergillus nidulans and 15 Aspergillus niger, were determined by a broth microdilution method with RPMI 1640 medium. No isolate was detected with an MIC of amphotericin B >2 mg/L. Itraconazole MICs >16 mg/L were detected for four Aspergillus fumigatus and one Aspergillus nidulans isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects*
  • Humans
  • Itraconazole / pharmacology*
  • Microbial Sensitivity Tests


  • Antifungal Agents
  • Itraconazole
  • Amphotericin B