Oxidized LDL and expression of monocyte adhesion molecules

Diabetes Res Clin Pract. 1999 Sep;45(2-3):123-6. doi: 10.1016/s0168-8227(99)00041-8.


Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / physiopathology
  • Cell Adhesion Molecules / genetics*
  • Cell Adhesion Molecules / physiology
  • Diabetes Mellitus / blood
  • Gene Expression Regulation / drug effects
  • Humans
  • Hyperlipoproteinemia Type III / blood
  • Lipoproteins, LDL / pharmacology
  • Lipoproteins, LDL / physiology*
  • Lysophosphatidylcholines / pharmacology
  • Receptors, LDL / physiology
  • Receptors, Oxidized LDL
  • Scavenger Receptors, Class E


  • Cell Adhesion Molecules
  • Lipoproteins, LDL
  • Lysophosphatidylcholines
  • OLR1 protein, human
  • Receptors, LDL
  • Receptors, Oxidized LDL
  • Scavenger Receptors, Class E
  • oxidized low density lipoprotein