Radiotherapy to control CNS lymphomatoid granulomatosis: a case report and review of the literature

Am J Hematol. 1999 Dec;62(4):239-41. doi: 10.1002/(sici)1096-8652(199912)62:4<239::aid-ajh7>;2-u.


Lymphomatoid granulomatosis (LG) is an uncommon but potentially fatal disease. The disease primarily involves the lungs; however, skin, renal, and central nervous system (CNS) are seen in varying proportions. Neurological involvement occurs in one third of the patients, and confers a worse prognosis. The use of radiotherapy to treat CNS involvement in LG has not been well studied. We report a case of a 33-year-old man with multiple CNS lesions treated successfully with radiotherapy and review 6 other cases in the literature using similar treatment. These cases support the use of radiotherapy for CNS involvement in LG.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / radiotherapy*
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / therapy
  • Lymphomatoid Granulomatosis / diagnosis
  • Lymphomatoid Granulomatosis / radiotherapy*
  • Lymphomatoid Granulomatosis / therapy
  • Magnetic Resonance Imaging
  • Male
  • Prednisone / administration & dosage
  • Remission Induction
  • Vincristine / administration & dosage


  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • CHOP protocol