Isolated lymph node T lymphoblastic transformation of chronic myeloid leukemia during interferon treatment

Am J Hematol. 1999 Dec;62(4):256-8. doi: 10.1002/(sici)1096-8652(199912)62:4<256::aid-ajh12>3.0.co;2-b.

Abstract

Isolated nodal T lymphoblastic transformation of chronic myeloid leukemia (CML) with the marrow still in chronic phase is rare. A case of CML treated by alpha-interferon developed this unusual complication. However, after successful treatment of the blastic transformation, the patient remained responsive to interferon and maintained a major cytogenetic response for over 2 years. This case illustrated a rare clinical progression of CML on interferon treatment to isolated nodal T lymphoblastic transformation. This unusual form of blastic transformation may have a better prognosis than other forms of blastic crisis.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow / pathology
  • Chromosomes, Human, Pair 22
  • Chromosomes, Human, Pair 9
  • Fusion Proteins, bcr-abl / genetics
  • Humans
  • Immunophenotyping
  • In Situ Hybridization, Fluorescence
  • Interferon-alpha / therapeutic use*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Lymph Nodes / pathology*
  • Lymphocyte Activation*
  • Male
  • Middle Aged
  • Remission Induction
  • T-Lymphocytes / pathology*
  • Translocation, Genetic

Substances

  • Interferon-alpha
  • Fusion Proteins, bcr-abl