WEREWOLF, a MYB-related protein in Arabidopsis, is a position-dependent regulator of epidermal cell patterning

Cell. 1999 Nov 24;99(5):473-83. doi: 10.1016/s0092-8674(00)81536-6.


The formation of the root epidermis of Arabidopsis provides a simple and elegant model for the analysis of cell patterning. A novel gene, WEREWOLF (WER), is described here that is required for position-dependent patterning of the epidermal cell types. The WER gene encodes a MYB-type protein and is preferentially expressed within cells destined to adopt the non-hair fate. Furthermore, WER is shown to regulate the position-dependent expression of the GLABRA2 homeobox gene, to interact with a bHLH protein, and to act in opposition to the CAPRICE MYB. These results suggest a simple model to explain the specification of the two root epidermal cell types, and they provide insight into the molecular mechanisms used to control cell patterning.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Arabidopsis / genetics
  • Arabidopsis / growth & development*
  • Arabidopsis Proteins*
  • Cell Lineage
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation, Plant
  • Genes, Homeobox
  • Genes, Plant*
  • Genes, Regulator
  • Homeodomain Proteins / biosynthesis
  • Hypocotyl / genetics
  • Hypocotyl / growth & development*
  • Models, Biological
  • Molecular Sequence Data
  • Plant Proteins / biosynthesis
  • Plant Proteins / genetics*
  • Plant Roots / genetics
  • Plant Roots / growth & development*
  • Proto-Oncogene Proteins c-myb*
  • Sequence Homology, Amino Acid
  • Tissue Distribution


  • ATR1 protein, Arabidopsis
  • Arabidopsis Proteins
  • CPC protein, Arabidopsis
  • DNA-Binding Proteins
  • GL2 protein, Arabidopsis
  • Homeodomain Proteins
  • Plant Proteins
  • Proto-Oncogene Proteins c-myb
  • WER protein, Arabidopsis

Associated data

  • GENBANK/AF126399