Chemotherapeutic neuropathy

Curr Opin Neurol. 1999 Oct;12(5):565-71. doi: 10.1097/00019052-199910000-00010.


Peripheral neurotoxicity is a dose-limiting side-effect for a number of effective chemotherapeutic agents, including platinum compounds, taxanes, and vinca alkaloids. New experimental chemotherapy drugs that cause neuropathy include suramin and Dolostatin-10. A better understanding of cellular mechanisms will lead to novel treatment strategies that will protect neurons without decreasing therapeutic efficacy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / adverse effects*
  • Drug Therapy, Combination
  • Humans
  • Neurons / drug effects
  • Peripheral Nervous System Diseases / chemically induced*
  • Peripheral Nervous System Diseases / therapy


  • Antineoplastic Agents