Synexpression groups in eukaryotes

Nature. 1999 Dec 2;402(6761):483-7. doi: 10.1038/990025.


In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or 'synexpression groups', show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cholesterol / biosynthesis
  • Cholesterol / genetics
  • Eukaryotic Cells / metabolism*
  • Evolution, Molecular
  • Gene Expression Regulation*
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Operon


  • Cholesterol