The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000

Nucleic Acids Res. 2000 Jan 1;28(1):45-8. doi: 10.1093/nar/28.1.45.


SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. Recent developments of the database include format and content enhancements, cross-references to additional databases, new documentation files and improvements to TrEMBL, a computer-annotated supplement to SWISS-PROT. TrEMBL consists of entries in SWISS-PROT-like format derived from the translation of all coding sequences (CDSs) in the EMBL Nucleotide Sequence Database, except the CDSs already included in SWISS-PROT. We also describe the Human Proteomics Initiative (HPI), a major project to annotate all known human sequences according to the quality standards of SWISS-PROT. SWISS-PROT is available at: and

MeSH terms

  • Animals
  • Databases, Factual*
  • Genome
  • Humans
  • Proteins / chemistry
  • Proteins / genetics*
  • Proteins / metabolism
  • Systems Integration


  • Proteins