SMART: a web-based tool for the study of genetically mobile domains

Nucleic Acids Res. 2000 Jan 1;28(1):231-4. doi: 10.1093/nar/28.1.231.


SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures ( ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Database Management Systems*
  • Information Storage and Retrieval
  • Internet*
  • Proteins / chemistry
  • Sequence Alignment*


  • Proteins