[Transurethral alprostadil (MUSE) in erectile dysfunction]

Arch Ital Urol Androl. 1999 Sep;71(4):249-51.
[Article in Italian]


The ideal therapy for erectile dysfunction should be easy, non invasive, painless, with a high success and a low side effects rate. Alternative methods of delivery drugs to the erectile body, instead of intracavernosal injection of vasoactive drugs such as prostaglandin, have been evaluated. Vasoactive agents can be administered topically into the urethral mucosa for absorption into the corpus spongiosum and transfer into the corpora cavernosa via small communicating veins. We report data from the literature and our experience with MUSE (Medicated Urethral System for Erection) for the treatment of erectile dysfunction. Penile pain or discomfort is the common adverse effect reported, while no priapism of fibrotic complication is reported. But local discomfort, limited efficacy, and cost are to be considered.

Publication types

  • English Abstract

MeSH terms

  • Administration, Topical
  • Aged
  • Alprostadil / administration & dosage*
  • Alprostadil / adverse effects
  • Erectile Dysfunction / drug therapy*
  • Evaluation Studies as Topic
  • Humans
  • Middle Aged
  • Urethra
  • Vasodilator Agents / administration & dosage*
  • Vasodilator Agents / adverse effects


  • Vasodilator Agents
  • Alprostadil