Signaling through Gp130: toward a general scenario of cytokine action

Growth Factors. 1999;17(2):81-91. doi: 10.3109/08977199909103518.


Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cytokines show functional pleiotropy and redundancy. Gp130 is a receptor subunit shared by the interleukin-6 family of cytokines. We describe and discuss signaling through gp130 in relation to a general scenario for cytokine signaling regulating cell growth, differentiation and survival.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • Cytokine Receptor gp130
  • Humans
  • Membrane Glycoproteins / physiology*
  • Models, Biological
  • Signal Transduction / physiology*


  • Antigens, CD
  • IL6ST protein, human
  • Membrane Glycoproteins
  • Cytokine Receptor gp130