Tumor-specific transplantation immunity to intracerebral challenge with cells from a methylnitrosourea- induced brain tumor

J Med. 1975;6(3-4):249-59.


Tumor-specific transplantation immunity was demonstrated in syngenic rats immunized and challenged with tumor cells (T9) from an N-methyl N-nitrosourea-induced brain tumor. All unimmunized rats and rats pretreated with normal glial cells in complete Freund's adjuvant or with adjuvant alone died of intracerebral (i.c.) neoplasia at approximately 3 weeks post-challenge. Rats which were immunized with T9 cells with or without adjuvant failed to develop i.c. tumors by 6 weeks even though the challenge dose was 2 logs greater than a dose which consistently resulted in neoplasia in unimmunized rats.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen-Antibody Reactions
  • Antigens, Neoplasm*
  • Astrocytoma / chemically induced
  • Astrocytoma / immunology*
  • Brain Neoplasms / chemically induced
  • Brain Neoplasms / immunology*
  • Disease Models, Animal
  • Freund's Adjuvant
  • Immunotherapy
  • Methylnitrosourea
  • Neoplasm Transplantation
  • Rats
  • Transplantation Immunology*
  • Transplantation, Homologous


  • Antigens, Neoplasm
  • Methylnitrosourea
  • Freund's Adjuvant