Quantitative trait locus detection using combined linkage/disequilibrium analysis

Genet Epidemiol. 1999;17 Suppl 1:S31-6. doi: 10.1002/gepi.1370170706.


We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by-state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcoholism / genetics
  • Alleles
  • Event-Related Potentials, P300 / genetics
  • Genetic Testing / methods*
  • Genome
  • Humans
  • Linkage Disequilibrium*
  • Models, Genetic*
  • Quantitative Trait, Heritable*