The transmission/disequilibrium test (TDT), sib-TDT and two combined tests have been implemented in an attempt to identify loci across the genome that may be involved in alcohol dependence. Since these tests are based on the existence of association between marker and disease loci, the low-density map used (13 cM) will have missed any disease loci situated between markers. Nevertheless, genome-wide suggestive linkage results were found at three markers--D6S474, D8S1715, and D12S372--two of which also gave nominally significant evidence by two-point linkage analysis. These are regions that deserve further investigation with respect to their involvement in alcohol dependence, and in order to evaluate the relative efficacy of the different methods used.