Usefulness of the epithelial tumor marker CA-125 in non-Hodgkin's lymphoma

Am J Clin Oncol. 1999 Dec;22(6):615-8. doi: 10.1097/00000421-199912000-00014.


CA-125, a commonly used tumor marker for epithelial ovarian cancer, is a glycoprotein found in normal tissues derived from coelomic epithelia. Increased serum levels of CA-125 have also been found in nongynecologic tumors and nonmalignant diseases involving the peritoneum. A few recent studies and sporadic case reports have reported increased CA-125 levels in patients with non-Hodgkin's lymphoma (NHL). In our study, we aimed to evaluate the serum levels of CA-125 in patients with NHL and determine its potential role to show disease activity in NHL. Serum levels of CA-125 were measured in 61 patients with NHL and were found to be correlated with clinical stage, site of involvement, and disease activity.

MeSH terms

  • Abdominal Neoplasms / pathology
  • Analysis of Variance
  • Biomarkers / analysis
  • Biomarkers, Tumor / blood*
  • Bone Marrow / pathology
  • Bone Neoplasms / pathology
  • CA-125 Antigen / analysis
  • CA-125 Antigen / blood*
  • Epithelium / metabolism
  • Female
  • Glycoproteins / analysis
  • Humans
  • L-Lactate Dehydrogenase / blood
  • Lymphoma, Non-Hodgkin / blood*
  • Lymphoma, Non-Hodgkin / diagnosis
  • Lymphoma, Non-Hodgkin / pathology
  • Male
  • Neoplasm Staging
  • Ovarian Neoplasms / diagnosis
  • Peritoneal Diseases / diagnosis
  • Prospective Studies
  • beta 2-Microglobulin / analysis


  • Biomarkers
  • Biomarkers, Tumor
  • CA-125 Antigen
  • Glycoproteins
  • beta 2-Microglobulin
  • L-Lactate Dehydrogenase