Sutureless and reduced suture anastomosis of hollow vessels with fibrin glue: a review

J Invest Surg. 1999 Sep-Oct;12(5):245-62. doi: 10.1080/089419399272377.


Research in reduced suture fibrin glue (FG) and sutureless FG anastomosis has been lagging behind FG utilization in other surgical fields. A review of the literature for vascular, esophageal, tracheal, gastrointestinal, common bile duct, ureteral, vas deferens, and Fallopian tube FG anastomosis indicates that reduced suture FG and sutureless FG procedures may be performed with less training, reduced operating time, leakage, ischemia, inflammation, and necrosis compared to sutured techniques. Reduced suture FG vascular anastomosis augments early anastomotic strength. Suture number for esophageal, tracheal, and tracheobronchial anastomoses can be reduced with FG. Bursting strength in pig small intestine and rat colon was lower at 4 days postoperatively, but returned to sutured strength at 7 days. Mortality was unaffected, and 18-month follow-up in sutureless FG intestinal anastomosis in pigs showed no stenosis. Preliminary ureteral studies have demonstrated successful sutureless FG and reduced suture FG laparoscopic techniques in pigs. Reduced suture FG and sutureless FG vas deferens anastomosis may reduce sperm granuloma rates, with increased patency and pregnancy rates. Patency and pregnancy rates have been similar for tubal FG, reduced suture FG, autologous fibrin glue (AFG), and sutured anastomosis. Any risk of viral transmission or immune response is eliminated by AFG. While there are few studies in many areas of FG hollow vessel anastomosis, the current literature illustrates many of the advantages of FG over other anastomotic techniques and should provide impetus for continued research in this promising field of surgery.

Publication types

  • Review

MeSH terms

  • Anastomosis, Surgical / methods*
  • Anastomosis, Surgical / trends
  • Animals
  • Common Bile Duct / surgery
  • Esophagus / surgery
  • Fallopian Tubes / surgery
  • Female
  • Fibrin Tissue Adhesive / therapeutic use*
  • Humans
  • Male
  • Sutures*
  • Tissue Adhesives / therapeutic use*
  • Trachea / surgery
  • Ureter / surgery
  • Vas Deferens / surgery


  • Fibrin Tissue Adhesive
  • Tissue Adhesives