Linkage and Association Study of the CTLA-4 Region in Coeliac Disease for Italian and Tunisian Populations

Tissue Antigens. 1999 Nov;54(5):527-30. doi: 10.1034/j.1399-0039.1999.540512.x.


Coeliac disease (CD) is a multifactorial disease for which there is an intensive search for genetic risk factors. Some authors found an association between the CTLA-4 region and CD. In the present work, we investigate the possible implication of the CTLA-4 region as a genetic risk factor for CD, through two statistical approaches: the maximum likelihood score (MLS) test in a large Italian sample of affected sib-pairs using polymorphic genetic markers on chromosome 2, and the transmission disequilibrium test (TDT) in continental Italian and Tunisian families using the CTLA-4 exon 1 49 A/G polymorphism. None of these approaches provides evidence for linkage or association between the CTLA-4 region and CD. This might result from a difference in the CTLA-4 region from population to population, either in its involvement as a risk factor or in the strength of linkage disequilibrium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abatacept
  • Adult
  • Antigens, CD
  • Antigens, Differentiation / genetics*
  • CTLA-4 Antigen
  • Celiac Disease / genetics*
  • Child
  • Family Health
  • Female
  • Genetic Linkage*
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Immunoconjugates*
  • Italy
  • Male
  • Polymorphism, Genetic*
  • Tunisia


  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human
  • Genetic Markers
  • Immunoconjugates
  • Abatacept