Current Biology of VEGF-B and VEGF-C

Curr Opin Biotechnol. 1999 Dec;10(6):528-35. doi: 10.1016/s0958-1669(99)00024-5.

Abstract

Endothelial growth factors and their receptors may provide important therapeutic tools for the treatment of pathological conditions characterised by defective or aberrant angiogenesis. Vascular endothelial growth factor (VEGF) is pivotal for vasculogenesis and for angiogenesis in normal and pathological conditions. VEGF-B and VEGF-C provide this gene family with additional functions, for example, VEGF-C also regulates lymphangiogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelial Growth Factors / chemistry
  • Endothelial Growth Factors / metabolism
  • Endothelial Growth Factors / physiology*
  • Humans
  • Ligands
  • Neovascularization, Physiologic / physiology
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Receptors, Growth Factor / metabolism
  • Receptors, Vascular Endothelial Growth Factor
  • Signal Transduction
  • Vascular Endothelial Growth Factor B
  • Vascular Endothelial Growth Factor C

Substances

  • Endothelial Growth Factors
  • Ligands
  • Receptors, Growth Factor
  • Vascular Endothelial Growth Factor B
  • Vascular Endothelial Growth Factor C
  • Receptor Protein-Tyrosine Kinases
  • Receptors, Vascular Endothelial Growth Factor