Nuclear receptor regulation of cholesterol and bile acid metabolism

Curr Opin Biotechnol. 1999 Dec;10(6):557-63. doi: 10.1016/s0958-1669(99)00031-2.


The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / biosynthesis
  • Bile Acids and Salts / metabolism*
  • Cholesterol / metabolism*
  • Feedback
  • Humans
  • Receptors, Cytoplasmic and Nuclear / physiology*


  • Bile Acids and Salts
  • Receptors, Cytoplasmic and Nuclear
  • Cholesterol