Cell adhesion molecules, signal transduction and cell growth

Curr Opin Cell Biol. 1999 Dec;11(6):737-44. doi: 10.1016/s0955-0674(99)00045-9.


Signals from dynamic cellular interactions between the extracellular matrix and neighboring cells ultimately input into the cellular decision-making process. These interactions form the basis of anchorage-dependent growth. Recent advances have provided the mechanistic details behind the ability of integrins, and other cell adhesion molecules (CAMs), to regulate both early signal transduction events initiated by soluble factors and downstream events more proximally involved in cell cycle progression. These actions appear to depend on the ability of CAMs to initiate the formation of organized structures that permit the efficient flow of information.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / physiology*
  • Cell Cycle
  • Cell Differentiation
  • Cell Division*
  • Integrins / physiology
  • Signal Transduction*


  • Cell Adhesion Molecules
  • Integrins