How do small GTPase signal transduction pathways regulate cell cycle entry?

Curr Opin Cell Biol. 1999 Dec;11(6):732-6. doi: 10.1016/s0955-0674(99)00044-7.


A variety of studies have shown that activation of the cell cycle machinery requires the participation of multiple signalling pathways. These pathways include Ras-dependent effectors such as the extracellular-signal related kinases, otherwise known as mitogen-activated protein kinases (ERKs, MAPKs), phosphatidylinositol 3 (PI3)-kinase and p21Ral pathways, as well as other signalling pathways regulated by the small GTPases p21Rho, p21Rac and p21Cdc42.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins*
  • Cell Cycle*
  • Cell Line
  • Cyclin D1 / metabolism
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • GTP Phosphohydrolases / physiology*
  • Gene Expression Regulation, Enzymologic*
  • MAP Kinase Signaling System
  • Microtubule-Associated Proteins / physiology
  • Signal Transduction*
  • Tumor Suppressor Proteins*


  • Cell Cycle Proteins
  • Microtubule-Associated Proteins
  • Tumor Suppressor Proteins
  • Cyclin D1
  • Cyclin-Dependent Kinase Inhibitor p27
  • Cyclin-Dependent Kinases
  • GTP Phosphohydrolases