Induction and differentiation of the neural crest

Curr Opin Cell Biol. 1999 Dec;11(6):695-8. doi: 10.1016/s0955-0674(99)00038-1.


The neural crest is a population of cells that forms at the junction between the epidermis and neural plate in vertebrate embryos. Recent progress has elucidated the identity and timing of molecular events responsible for the earliest steps in neural crest development, particularly those involving the induction and its migration. Concomitantly, advances have been made in the identification, purification and generation of neural crest stem cells at various developmental stages that deepens our understanding of the plasticity and restriction of neural crest differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Movement
  • Chick Embryo
  • Mice
  • Neural Crest / cytology
  • Neural Crest / embryology*
  • Proto-Oncogene Proteins / physiology
  • Stem Cells / physiology
  • Transforming Growth Factor beta / physiology
  • Wnt Proteins
  • Xenopus
  • Zebrafish
  • Zebrafish Proteins*


  • Proto-Oncogene Proteins
  • Transforming Growth Factor beta
  • Wnt Proteins
  • Zebrafish Proteins
  • wnt8b protein, zebrafish