Effectiveness of pneumococcal polysaccharide vaccine for preschool-age children with chronic disease

Emerg Infect Dis. Nov-Dec 1999;5(6):828-31. doi: 10.3201/eid0506.990616.

Abstract

To estimate the effectiveness of pneumococcal polysaccharide vaccine, we serotyped isolates submitted to the Pneumococcal Sentinel Surveillance System from 1984 to 1996 from 48 vaccinated and 125 unvaccinated children 2 to 5 years of age. Effectiveness against invasive disease caused by serotypes included in the vaccine was 63%. Effectiveness against serotypes in the polysaccharide vaccine but not in a proposed seven-valent protein conjugate vaccine was 94%.

MeSH terms

  • Bacterial Vaccines*
  • Child, Preschool
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / microbiology
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines
  • Sentinel Surveillance
  • Serotyping
  • Sickle Cell Trait
  • Streptococcus pneumoniae / classification*
  • Treatment Outcome
  • United States / epidemiology

Substances

  • Bacterial Vaccines
  • Pneumococcal Vaccines