The kelch repeat superfamily of proteins: propellers of cell function

Trends Cell Biol. 2000 Jan;10(1):17-24. doi: 10.1016/s0962-8924(99)01673-6.


The kelch motif was discovered as a sixfold tandem element in the sequence of the Drosophila kelch ORF1 protein. The repeated kelch motifs predict a conserved tertiary structure, a beta-propeller. This module appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this growing superfamily are present throughout the cell and extracellularly and have diverse activities. In this review, we discuss current information concerning the structural organization of kelch repeat proteins, their biological roles and the molecular basis of their action.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Carrier Proteins* / chemistry
  • Carrier Proteins* / genetics
  • Carrier Proteins* / metabolism
  • Drosophila Proteins*
  • Humans
  • Insect Proteins* / chemistry
  • Insect Proteins* / genetics
  • Insect Proteins* / metabolism
  • Molecular Sequence Data
  • Protein Conformation
  • Repetitive Sequences, Nucleic Acid
  • Structure-Activity Relationship


  • Carrier Proteins
  • Drosophila Proteins
  • I-element-gag protein, Drosophila
  • Insect Proteins