Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 354 (1390), 1635-40

The Pathology of Multiple Sclerosis and Its Evolution


The Pathology of Multiple Sclerosis and Its Evolution

H Lassmann. Philos Trans R Soc Lond B Biol Sci.


The pathology of multiple sclerosis (MS) was defined more than a century ago as a chronic inflammatory process which is associated with widespread primary demyelination and glial scarring. In this short review we discuss controversial issues on (i) the relationship between inflammation and demyelination, (ii) the various possible mechanisms of myelin destruction, and (iii) axonal involvement in this disease. We suggest that the disease process of MS is more complex that previously believed.

Similar articles

See all similar articles

Cited by 17 PubMed Central articles

See all "Cited by" articles


    1. Ann Neurol. 1994 Jan;35(1):89-97 - PubMed
    1. J Clin Invest. 1998 Sep 15;102(6):1265-73 - PubMed
    1. Cytokine. 1993 Nov;5(6):583-8 - PubMed
    1. Ultrastruct Pathol. 1994 Jan-Apr;18(1-2):3-13 - PubMed
    1. Neuropathol Appl Neurobiol. 1994 Apr;20(2):152-62 - PubMed

Publication types

MeSH terms