Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma). The third Pan American Association of Ophthalmology and American Journal of Ophthalmology Lecture

Am J Ophthalmol. 1975 Dec;80(6):975-90. doi: 10.1016/0002-9394(75)90326-8.


The clinicopathologic review of 33 well-documented cases of granulocytic sarcoma on file in the Registry of Ophthalmic Pathology confirmed the facts that this tumor is encountered mainly in children, that boys are affected more frequently than girls, and that white Americans appear to be less vulnerable than other ethnic groups. While granulocytic sarcoma is a variant of granulocytic leukemia, the tumor may appear before, after, or concomitantly with hematologic evidence of leukemia. In the present series only four of the 33 patients were already known to have leukemia when they were first seen by an ophthalmologist for their orbital, ocular, or adnexal lessions. The Leder stain has proved extremely helpful in arriving at a definitive histopathologic diagnosis. Accurate diagnosis is important to prevent inappropriate medical or surgical treatment and to indicate the need for vigorous antileukemic chemotherapy. Prognosis at best is poor.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Esterases / metabolism
  • Eye Neoplasms / diagnosis*
  • Eye Neoplasms / enzymology
  • Eye Neoplasms / pathology
  • Eyelid Neoplasms / diagnosis
  • Female
  • Humans
  • Infant
  • Leukemia / diagnosis*
  • Leukemia / enzymology
  • Leukemia / pathology
  • Leukemia, Myeloid / diagnosis*
  • Leukemia, Myeloid / enzymology
  • Leukemia, Myeloid / pathology
  • Male
  • Middle Aged
  • Orbital Neoplasms / diagnosis
  • Prognosis
  • Sex Factors


  • Esterases