A genetic dissection of the retinoid signalling pathway in the mouse

Proc Nutr Soc. 1999 Aug;58(3):609-13. doi: 10.1017/s0029665199000798.


To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Mice
  • Mice, Knockout
  • Receptors, Retinoic Acid / genetics
  • Receptors, Retinoic Acid / physiology
  • Retinoid X Receptors
  • Retinoids*
  • Signal Transduction / genetics*
  • Transcription Factors / genetics
  • Transcription Factors / physiology


  • Receptors, Retinoic Acid
  • Retinoid X Receptors
  • Retinoids
  • Transcription Factors