Pantoprazole, Prout and the proton pump

Hosp Med. 1999 Jul;60(7):500-4. doi: 10.12968/hosp.1999.60.7.1743.

Abstract

Pantoprazole is a proton pump inhibitor which has recently had its clinical license extended to include maintenance therapy for the treatment of reflux oesophagitis, Helicobacter pylori eradication and short-term intravenous administration. This article reviews the history of gastric acid secretion and examines the role of proton pump inhibitors, particularly pantoprazole, in the treatment of acid-related disorders.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents / therapeutic use*
  • Benzimidazoles / therapeutic use*
  • Drug Interactions
  • Female
  • Gastric Acid / metabolism*
  • Gastric Juice / chemistry
  • History, 18th Century
  • History, 19th Century
  • History, 20th Century
  • Humans
  • Omeprazole / analogs & derivatives
  • Pantoprazole
  • Peptic Ulcer / drug therapy*
  • Pregnancy
  • Proton Pump Inhibitors*
  • Sulfoxides / therapeutic use*
  • Treatment Outcome

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Ulcer Agents
  • Benzimidazoles
  • Proton Pump Inhibitors
  • Sulfoxides
  • Pantoprazole
  • Omeprazole