Redox regulation of signal transduction in mammalian cells

Biochem Pharmacol. 2000 Jan 1;59(1):35-41. doi: 10.1016/s0006-2952(99)00298-1.


This mini-review addresses the mechanism of ultraviolet-light-induced activation of receptor tyrosine kinases. The experimental approach into this mechanism revealed the existence of redox regulation of signal transduction in mammalian cells. It is postulated that, in addition to responsiveness to oxidative attacks from outside, redox regulation of specific redox-sensitive proteins likely represents an important physiological mechanism.

Publication types

  • Review

MeSH terms

  • Animals
  • Ligands
  • Mammals
  • Metals / metabolism
  • Metals / toxicity
  • Oxidation-Reduction
  • Protein Tyrosine Phosphatases / metabolism*
  • Protein Tyrosine Phosphatases / radiation effects
  • Receptor Protein-Tyrosine Kinases / drug effects
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Substrate Specificity
  • Ultraviolet Rays


  • Ligands
  • Metals
  • Receptor Protein-Tyrosine Kinases
  • Protein Tyrosine Phosphatases