Abstract
We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.
MeSH terms
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Antirheumatic Agents* / adverse effects
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Arthritis, Rheumatoid / diagnostic imaging
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Arthritis, Rheumatoid / drug therapy
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Arthritis, Rheumatoid / surgery*
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Bony Callus / diagnostic imaging
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Bony Callus / drug effects*
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Contraindications
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Humans
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Male
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Metatarsal Bones / physiopathology
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Metatarsal Bones / surgery
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Methotrexate* / adverse effects
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Middle Aged
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Osteotomy*
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Radiography
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Tibia / physiopathology
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Tibia / surgery
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Treatment Outcome
Substances
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Antirheumatic Agents
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Methotrexate