Bone non-union after osteotomy in patients treated with methotrexate

J Rheumatol. 1999 Dec;26(12):2695-7.

Abstract

We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.

Publication types

  • Case Reports

MeSH terms

  • Antirheumatic Agents* / adverse effects
  • Arthritis, Rheumatoid / diagnostic imaging
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / surgery*
  • Bony Callus / diagnostic imaging
  • Bony Callus / drug effects*
  • Contraindications
  • Humans
  • Male
  • Metatarsal Bones / physiopathology
  • Metatarsal Bones / surgery
  • Methotrexate* / adverse effects
  • Middle Aged
  • Osteotomy*
  • Radiography
  • Tibia / physiopathology
  • Tibia / surgery
  • Treatment Outcome

Substances

  • Antirheumatic Agents
  • Methotrexate