Alpha/beta hydrolase fold enzymes: the family keeps growing

Curr Opin Struct Biol. 1999 Dec;9(6):732-7. doi: 10.1016/s0959-440x(99)00037-8.


The alpha/beta hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family.

Publication types

  • Review

MeSH terms

  • Aspartic Acid / chemistry
  • Binding Sites
  • Glutamic Acid / chemistry
  • Hydrolases / chemistry
  • Hydrolases / metabolism*
  • Models, Molecular
  • Protein Conformation
  • Protein Folding


  • Aspartic Acid
  • Glutamic Acid
  • Hydrolases