Cyclin-dependent kinases: inhibition and substrate recognition

Curr Opin Struct Biol. 1999 Dec;9(6):738-44. doi: 10.1016/s0959-440x(99)00038-x.


Four unresolved issues of cyclin-dependent kinase (CDK) regulation have been addressed by structural studies this year - the mechanism of CDK inhibition by members of the INK4 family of CDK inhibitors, consensus substrate sequence recognition by CDKs, the role of the cyclin subunit in substrate recognition and the structural mechanism underlying CDK inhibition by phosphorylation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Cell Cycle Proteins / metabolism
  • Cyclin-Dependent Kinases / antagonists & inhibitors*
  • Cyclin-Dependent Kinases / chemistry
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / metabolism
  • Models, Molecular
  • Molecular Structure
  • Phosphorylation
  • Substrate Specificity


  • Cell Cycle Proteins
  • Cyclins
  • Cyclin-Dependent Kinases