Diversity in Protein Recognition by PTB Domains

Curr Opin Struct Biol. 1999 Dec;9(6):690-5. doi: 10.1016/s0959-440x(99)00031-7.


Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that recognize phosphorylated Asn-Pro-Xxx-p Tyr-containing proteins. Recent binding and structural studies of PTB domain complexes with target peptides have revealed a number of deviations from the previously described mode of interaction, with respect to both the sequences of possible targets and their structures within the complexes. This diversity of recognition by PTB domains extends and strengthens our general understanding of modular binding domain recognition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Phosphorylation
  • Phosphotyrosine / metabolism*
  • Protein Binding
  • Proteins / chemistry
  • Proteins / metabolism*


  • Proteins
  • Phosphotyrosine