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Review
, 9 (6), 722-31

Structural and Mechanistic Studies on 2-oxoglutarate-dependent Oxygenases and Related Enzymes

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Review

Structural and Mechanistic Studies on 2-oxoglutarate-dependent Oxygenases and Related Enzymes

C J Schofield et al. Curr Opin Struct Biol.

Abstract

Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxygen activation that involve iron-mediated electron transfer.

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