Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

Curr Opin Struct Biol. 1999 Dec;9(6):722-31. doi: 10.1016/s0959-440x(99)00036-6.


Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxygen activation that involve iron-mediated electron transfer.

Publication types

  • Review

MeSH terms

  • Amino Acid Oxidoreductases / metabolism
  • Catalysis
  • Ketoglutaric Acids / metabolism*
  • Models, Molecular
  • Oxidoreductases / metabolism
  • Oxygenases / chemistry
  • Oxygenases / metabolism*
  • Protein Conformation
  • Substrate Specificity


  • Ketoglutaric Acids
  • Oxidoreductases
  • Oxygenases
  • isopenicillin N synthetase
  • Amino Acid Oxidoreductases
  • 1-aminocyclopropane-1-carboxylic acid oxidase