Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

Neuropharmacology. 1999 Dec;38(12):1917-20. doi: 10.1016/s0028-3908(99)00083-0.


Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Down Syndrome / genetics*
  • Excitatory Postsynaptic Potentials / genetics*
  • Hippocampus / physiology
  • Intellectual Disability / genetics*
  • Long-Term Potentiation / genetics*
  • Mice