Antimicrobial use in febrile children diagnosed with respiratory tract illness in an emergency department

Pediatr Infect Dis J. 1999 Dec;18(12):1078-80. doi: 10.1097/00006454-199912000-00010.


Background: In an era of increasing antibiotic resistance, the prevalence of antibiotic usage and associated factors should be ascertained to optimize their use. We set out to determine the prevalence of antibiotic use in febrile children diagnosed with respiratory tract illnesses at a children's hospital emergency department; to determine how often viral studies were conducted; and to identify patient characteristics associated with antibiotic use.

Methods: We conducted a retrospective study of antibiotic use in febrile children 3 months to 10 years old presenting with respiratory illnesses during two 1-month periods. Patient charts and laboratory tests were reviewed. Antibiotic use was related to diagnosis by logistic regression.

Results: A total of 836 patient visits were selected. Antibiotics were prescribed for otitis media in 96% of patients, for pneumonia in 100%, for pharyngitis in 66%, for bronchiolitis in 38%, for reactive airway disease in 24% and for viral or "upper respiratory tract illness" in 14%. For viral illness or upper respiratory tract infection, antibiotic use was associated with a fever duration of >48 h [odds ratio (OR), 3.2; 95% confidence interval (CI) 1.7, 5.9] and having a chest radiograph performed (OR 2.1; 95% CI 1.02, 4.37). Patients with pharyngitis who had a throat swab were less likely to receive an antibiotic (OR 0.08; 95% CI 0.02, 0.4) than those who did not have a swab. In this emergency department antibiotic use for these indications decreased by 11% during the 1997 to 1998 study interval (P < 0.001).

Conclusion: Antibiotics were commonly prescribed for pharyngitis, bronchiolitis and reactive airway disease, which are conditions principally caused by viruses. Addressing reasons why there is a difference between guidelines and antibiotic use in these conditions may be important.

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Canada
  • Child
  • Child, Preschool
  • Drug Utilization
  • Emergency Service, Hospital / statistics & numerical data*
  • Female
  • Fever / complications
  • Fever / microbiology
  • Fever / therapy*
  • Hospitals, Pediatric / statistics & numerical data*
  • Humans
  • Infant
  • Logistic Models
  • Male
  • Respiratory Tract Diseases / complications
  • Respiratory Tract Diseases / microbiology
  • Respiratory Tract Diseases / therapy*
  • Retrospective Studies
  • Virus Diseases / diagnosis


  • Anti-Bacterial Agents