Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice

C R Acad Sci III. 1999 Oct;322(10):831-6. doi: 10.1016/s0764-4469(00)86647-0.

Abstract

Genes implicated in consumption of a bitter compound, sucrose octaacetate (SOA), were investigated using a full genomic scanning strategy. For a 0.1 mM concentration, two QTL reached 5.8 and 6.5 lod scores on chromosomes 2 (77 cM) and 11 (14 cM), respectively. For a 1 mM concentration, the Soa linkage on chromosome 6 (58 cM, lod score 9.4) was replicated, and another QTL was found on chromosome 19 (15 cM, lod score 3.2). Candidacy of previously identified genes in the close vicinity of the peak of the QTL was examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Female
  • Genetic Linkage
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred NZB
  • Polymorphism, Genetic
  • Sucrose / analogs & derivatives*
  • Taste / genetics*

Substances

  • sucrose octaacetate
  • Sucrose