Controlling the sugar bowl. Regulation of glucose homeostasis in children

Endocrinol Metab Clin North Am. 1999 Dec;28(4):663-94. doi: 10.1016/s0889-8529(05)70096-7.


In this article, the authors have attempted to provide a reasonable, working, and dynamic model incorporating a number of factors that are known to be involved in the regulation of glucose homeostasis in infants, children, and adults. Through the understanding of this model and its application, it is hoped that some of the authors' speculations regarding the pathophysiology of hyperglycemia and hypoglycemia might be challenged and either supported or rejected. In the meantime, the model can provide a framework for several of the facts and observations about the regulation of glucose homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Blood Glucose / metabolism*
  • Carbohydrate Metabolism, Inborn Errors
  • Child
  • Child, Preschool
  • Gluconeogenesis
  • Glycogen / metabolism
  • Homeostasis*
  • Humans
  • Insulin / physiology
  • Kinetics


  • Blood Glucose
  • Insulin
  • Glycogen