A meta-analysis of risk estimates for prostate cancer related to tire and rubber manufacturing operations

J Occup Environ Med. 1999 Dec;41(12):1079-84. doi: 10.1097/00043764-199912000-00012.


Studies investigating the association between prostate cancer and exposure to the tire and rubber manufacturing environment have reported weak and inconsistent results. A meta-analysis of nine cohort studies that used standard mortality ratios and three case-control studies that used odds ratios was conducted. The pooled results from the nine cohort studies showed a standard mortality ratio of 101 (95% confidence interval [CI] = 93,110), whereas the pooled results from the three case-control studies showed on odds ratio of 1.10 (95% CI = 0.94, 1.29). The standard mortality ratios were converted to odds ratios by dividing by 100. The overall pooled risk estimate from all 12 studies was 1.03 (95% CI = 0.96, 1.11). The conclusion of this meta-analysis is that work exposure in a rubber and tire manufacturing environment does not result in an increased risk of prostate cancer.

Publication types

  • Meta-Analysis

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Humans
  • Industry*
  • Male
  • Manufactured Materials
  • Middle Aged
  • Occupational Exposure
  • Occupational Health*
  • Odds Ratio
  • Prostatic Neoplasms / etiology*
  • Risk Assessment
  • Rubber


  • Rubber