Abstract
Tuberculosis is a worldwide public health threat caused by Mycobacterium tuberculosis. All mycobacteria express a unique cell envelope glycolipid, lipoarabinomannan, which can be released at sites of infection. Lipoarabinomannan is a potential virulence factor which can bind to leukocytes and modulate immune responses. Here, we provide an overview of the interactions of mycobacteria and lipoarabinomannan with immune cells.
MeSH terms
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Animals
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Chemokines / metabolism
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Chemotaxis, Leukocyte
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Lipopolysaccharides / chemistry
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Lipopolysaccharides / metabolism*
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Macrophage Activation
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Macrophages, Alveolar / immunology
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Macrophages, Alveolar / metabolism
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Mice
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Mycobacterium tuberculosis / metabolism
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Mycobacterium tuberculosis / pathogenicity*
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Phagocytosis
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Tuberculosis / immunology
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Tuberculosis / microbiology*
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Virulence
Substances
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Chemokines
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Lipopolysaccharides
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lipoarabinomannan