Abstract
Over a 4-year period, antioxidant therapy (vitamin E) was compared with high-dose statin therapy in 15 patients with homozygous familial hypercholesterolemia. Carotid intima-media thickness, used as an in vivo assessment of atherosclerosis, progressed rapidly during the period of vitamin E therapy but regressed on statin therapy.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Anticholesteremic Agents / therapeutic use*
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Arteriosclerosis / blood
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Arteriosclerosis / etiology
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Arteriosclerosis / genetics
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Arteriosclerosis / prevention & control*
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Atorvastatin
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Carotid Arteries / pathology
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Child
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Child, Preschool
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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DNA / genetics
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Disease Progression
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Female
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Heptanoic Acids / therapeutic use*
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Homozygote
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Humans
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Hyperlipoproteinemia Type II / blood
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Hyperlipoproteinemia Type II / complications
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Hyperlipoproteinemia Type II / drug therapy*
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Hyperlipoproteinemia Type II / genetics
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Male
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Mutation
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Pyrroles / therapeutic use*
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Receptors, LDL / genetics
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Simvastatin / therapeutic use*
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Treatment Outcome
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Triglycerides / blood
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Tunica Intima / pathology
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Vitamin E / therapeutic use*
Substances
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Anticholesteremic Agents
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Cholesterol, HDL
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Cholesterol, LDL
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Heptanoic Acids
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Pyrroles
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Receptors, LDL
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Triglycerides
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Vitamin E
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DNA
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Atorvastatin
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Simvastatin