Efficacy of vitamin E compared with either simvastatin or atorvastatin in preventing the progression of atherosclerosis in homozygous familial hypercholesterolemia

Am J Cardiol. 1999 Dec 1;84(11):1344-6, A7. doi: 10.1016/s0002-9149(99)00570-6.

Abstract

Over a 4-year period, antioxidant therapy (vitamin E) was compared with high-dose statin therapy in 15 patients with homozygous familial hypercholesterolemia. Carotid intima-media thickness, used as an in vivo assessment of atherosclerosis, progressed rapidly during the period of vitamin E therapy but regressed on statin therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anticholesteremic Agents / therapeutic use*
  • Arteriosclerosis / blood
  • Arteriosclerosis / etiology
  • Arteriosclerosis / genetics
  • Arteriosclerosis / prevention & control*
  • Atorvastatin
  • Carotid Arteries / pathology
  • Child
  • Child, Preschool
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • DNA / genetics
  • Disease Progression
  • Female
  • Heptanoic Acids / therapeutic use*
  • Homozygote
  • Humans
  • Hyperlipoproteinemia Type II / blood
  • Hyperlipoproteinemia Type II / complications
  • Hyperlipoproteinemia Type II / drug therapy*
  • Hyperlipoproteinemia Type II / genetics
  • Male
  • Mutation
  • Pyrroles / therapeutic use*
  • Receptors, LDL / genetics
  • Simvastatin / therapeutic use*
  • Treatment Outcome
  • Triglycerides / blood
  • Tunica Intima / pathology
  • Vitamin E / therapeutic use*

Substances

  • Anticholesteremic Agents
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Heptanoic Acids
  • Pyrroles
  • Receptors, LDL
  • Triglycerides
  • Vitamin E
  • DNA
  • Atorvastatin
  • Simvastatin