Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function

Biomaterials. 1999 Dec;20(23-24):2287-303. doi: 10.1016/s0142-9612(99)00181-7.


Surface reactivity is one of the common characteristics of bone bioactive ceramics. It contributes to their bone bonding ability and their enhancing effect on bone tissue formation. During implantation, reactions occur at the material-tissue interface that lead to time-dependent changes in the surface characteristics of the implant material and the tissues at the interface. This review describes some of the current concepts regarding the surface reactivity of bone bioactive materials and its effect on attachment, proliferation, differentiation and mineralization of bone cells.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 3T3 Cells
  • Alkaline Phosphatase / metabolism
  • Animals
  • Biocompatible Materials / metabolism*
  • Blood Proteins / metabolism
  • Bone and Bones / metabolism*
  • Bone and Bones / physiology*
  • Bone and Bones / ultrastructure
  • Calcium Phosphates / metabolism
  • Cells, Cultured
  • Dogs
  • Fibronectins / metabolism
  • Glass*
  • Mice
  • Osteoblasts / metabolism
  • Stress, Mechanical
  • Time Factors
  • Tissue Transplantation


  • Biocompatible Materials
  • Blood Proteins
  • Calcium Phosphates
  • Fibronectins
  • alpha-tricalcium phosphate
  • tetracalcium phosphate
  • calcium phosphate, monobasic, anhydrous
  • calcium phosphate
  • Alkaline Phosphatase
  • calcium phosphate, dibasic, anhydrous