Getting to the guts of enteroendocrine differentiation

Nat Genet. 2000 Jan;24(1):3-4. doi: 10.1038/71653.

Abstract

The endodermal epithelium of vertebrates generates many types of enteroendocrine cells, including the insulin- and glucagon-secreting cells of the islets of Langerhans. Two studies disclose that Notch signalling controls which cells differentiate as enteroendocrine cells-a finding with implications for therapeutic strategy.

Publication types

  • News

MeSH terms

  • Animals
  • Cell Differentiation*
  • Digestive System / cytology*
  • Digestive System / metabolism
  • Endocrine Glands / cytology*
  • Endocrine Glands / metabolism
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Mice
  • Mice, Knockout
  • Receptors, Notch
  • Signal Transduction

Substances

  • Membrane Proteins
  • Receptors, Notch