Peptidic immunosuppressants from the fungus Trichoderma polysporum

Bioorg Med Chem Lett. 1999 Dec 20;9(24):3393-6. doi: 10.1016/s0960-894x(99)00621-6.

Abstract

Three new 10-residue lipopeptaibols, trichopolyns III-V have been isolated from the fungus Trichoderma polysporum together with the known trichopolyns I and II. Structure determination has been achieved on the basis of spectroscopic and chemical evidence. These peptides have been shown to suppress the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antimicrobial Cationic Peptides
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / isolation & purification*
  • Immunosuppressive Agents / pharmacology
  • Lymphocyte Culture Test, Mixed
  • Mass Spectrometry / methods
  • Mice
  • Peptides*
  • Protein Conformation
  • Trichoderma / chemistry*

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • Immunosuppressive Agents
  • Peptides
  • trichopolyn