Delta opioid binding selectivity of 3-ether analogs of naltrindole

Bioorg Med Chem Lett. 1999 Dec 20;9(24):3435-8. doi: 10.1016/s0960-894x(99)00622-8.


Masking of the 3-phenol of naltrindole as a range of ethers caused a decrease in binding affinity at all three opiate receptors (mu, kappa, delta), however for the methyl ether, the reduction in affinity at both mu and kappa was greater than at delta, thereby increasing delta binding selectivity.

MeSH terms

  • Naltrexone / analogs & derivatives*
  • Naltrexone / chemistry
  • Naltrexone / metabolism
  • Narcotic Antagonists / chemistry
  • Narcotic Antagonists / metabolism*
  • Protein Binding
  • Receptors, Opioid, delta / metabolism*


  • Narcotic Antagonists
  • Receptors, Opioid, delta
  • Naltrexone
  • naltrindole