Linkage disequilibrium and recombination in hominid mitochondrial DNA

P Awadalla; A Eyre-Walker; J M Smith

doi:10.1126/science.286.5449.2524

Linkage disequilibrium and recombination in hominid mitochondrial DNA

Science. 1999 Dec 24;286(5449):2524-5. doi: 10.1126/science.286.5449.2524.

Authors

P Awadalla¹, A Eyre-Walker, J M Smith

Affiliation

¹ Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 1JT, UK.

PMID: 10617471
DOI: 10.1126/science.286.5449.2524

Abstract

The assumption that human mitochondrial DNA is inherited from one parent only and therefore does not recombine is questionable. Linkage disequilibrium in human and chimpanzee mitochondrial DNA declines as a function of the distance between sites. This pattern can be attributed to one mechanism only: recombination.

Publication types

Comment
Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA, Mitochondrial / genetics*
Evolution, Molecular
Fathers
Female
Hominidae / genetics*
Humans
Linkage Disequilibrium*
Male
NADH Dehydrogenase / genetics
Pan troglodytes / genetics*
Polymorphism, Restriction Fragment Length
Recombination, Genetic*

Substances

DNA, Mitochondrial
NADH Dehydrogenase