Linkage disequilibrium and recombination in hominid mitochondrial DNA

Science. 1999 Dec 24;286(5449):2524-5. doi: 10.1126/science.286.5449.2524.


The assumption that human mitochondrial DNA is inherited from one parent only and therefore does not recombine is questionable. Linkage disequilibrium in human and chimpanzee mitochondrial DNA declines as a function of the distance between sites. This pattern can be attributed to one mechanism only: recombination.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA, Mitochondrial / genetics*
  • Evolution, Molecular
  • Fathers
  • Female
  • Hominidae / genetics*
  • Humans
  • Linkage Disequilibrium*
  • Male
  • NADH Dehydrogenase / genetics
  • Pan troglodytes / genetics*
  • Polymorphism, Restriction Fragment Length
  • Recombination, Genetic*


  • DNA, Mitochondrial
  • NADH Dehydrogenase